Effect of dapagliflozin on cardiac function and ventricular remodeling in patients with acute myocardial infarction complicated with type 2 diabetes mellitus
Lin Junjie
Wang Lele
Wang Dan
Fan Xiaodan
Dai Yanan
Tang Nan
Li Kangming
Qi Chunmei
Abstract：Objective To observe the cardiovascular benefits and safety of dapagliflozin in the treatment of acute myocardial infarction and type 2 diabetes mellitus.Methods A total of 122 patients with acute myocardial infarction combined with type 2 diabetes mellitus who were hospitalized in the Department of Cardiology of the Second Affiliated Hospital of Xuzhou Medical University from January 2021 to January 2022 were admitted.Patients were randomly divided into an experimental group and a control group,with 61 cases in each group,the control group was given basic treatment,and the experimental group added dapagliflozin to the basic treatment regimen.The differences in cardiovascular risk factors,cardiac function,and ventricular remodeling indexes between the two groups after 6 months were compared,and the occurrence of adverse reactions during treatment was monitored.Results There was no significant difference in baseline data between the two groups before treatment(P>0.05).The comparison of changes in cardiac function indicators after treatment between the two groups showed that there was no significant difference in ΔLVEF between the two groups(P>0.05);compared with the control group,the differences in ΔLVM,ΔLVMI,and ΔNT-proBNP in the experimental group were statistically significant(P<0.05).The comparison of cardiovascular risk factors after treatment between the two groups showed that there were no significant differences in ΔCr,ΔUA,ΔeGFR,ΔLDL,ΔHDL,ΔTC,and ΔTG between the two groups(P>0.05);compared with the control group,the differences in ΔBMI,ΔSBP,ΔDBP,ΔFPG,and ΔHbA1c in the experimental group were statistically significant(P<0.05).There was no significant difference in the incidence of drug-related adverse reactions between the two groups(P>0.05).Conclusion The early application of dapagliflozin in patients with type 2 diabetes mellitus after acute myocardial infarction can improve cardiac function,reverse ventricular remodeling,and achieve better blood glucose,blood pressure,and body quality control effects,and good safety.
Keywords：Acute myocardial infarctionType 2 diabetesSGLT2 inhibitorsDapagliflozinVentricular reconstruction
Publication Date：2023-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1076-1080 )