Correlation of lipoprotein(a)and lipoprotein(a)/HDL-C with in-stent restenosis after PCI

Li Jingsha; Ru Leisheng; Ma Yanzhuo; Kong Lingfeng; Bu Yuntao; Ding Chao

doi:10.3969/j.issn.1674-4055.2023.09.11

Abstract：Objective To investigate the correlation between lipoprotein(a)[LP(a)],LP(a)/HDL-C ratio,and in-stent restenosis.Methods Ninety-three patients who underwent stent implantation were analyzed retrospectively,including 49 patients in the in-stent restenosis group and 44 in the non-restenosis group.The differences in lipid parameters[LDL-C,HDL-C,LDL-C/HDL-C,LP(a),LP(a)/HDL-C]were analyzed between the two groups.The correlation between LP(a),LP(a)/HDL-C,and LDL-C/HDL-C was analyzed.The LP(a)/HDL-C ratio was divided into three groups:low LP(a)/HDL-C,medium LP(a)/HDL-C,and high LP(a)/HDL-C group.According to the incidence of restenosis and the correlation between LP(a),LP(a)/HDL-C,and LDL-C/HDL-C,the relationship between LP(a),LP(a)/HDL-C ratio and in-stent restenosis was investigated.Results ①There was no difference in LDL-C and HDL-C between the two groups(P>0.05).②The levels of LDL-C/HDL-C,LP(a),and LP(a)/HDL-C in the in-stent restenosis group were higher than those in the non-restenosis group(P<0.05).③Both LP(a)and LP(a)/HDL-C were significantly correlated with LDL-C/HDL-C,and LP(a)/HDL-C was more strongly correlated with LDL-C/HDL-C(r=0.253,P=0.019 vs.r=0.382,P=0.000).④The rate of in-stent restenosis in the high LP(a)/HDL-C group was higher than that in the low LP(a)/HDL-C group(P<0.05).⑤Multiple Logistic regression analysis showed that LDL-C/HDL-C,LP(a),and LP(a)/HDL-C were independent risk factors for in-stent restenosis.⑥ROC curve results showed that LDL-C/HDL-C,LP(a),and LP(a)/HDL-C had predictive value for in-stent restenosis,and the area under the curve of LP(a)/HDL-C was greater than that of LDL-C/HDL-C and LP(a).Conclusions LP(a)and LP(a)/HDL-C ratio are closely related to in-stent restenosis and are independent risk factors.LP(a)/HDL-C ratio has a higher predictive value.