Hyperuricemia as a marker of heart failure with preserved ejection fraction in elderly patients with atrial fibrillation
Ji Yutong
Lin Zhongqiu
Xu Jiajia
Liu Ruiying
Huang Jianyu
Quan Xinxue
Xie Zhiquan
Xu Lin
Abstract：Objective Study on the correlation between hyperuricemia and ejection fraction preserving heart failure in elderly patients with atrial fibrillation.Methods A total of 311 elderly patients(75～100 years old)with AF were selected,who were hospitalized in the cadre ward of the General Hospital of Southern Theatre Command Hospital from January 2015 to May 2020.Vital signs and laboratory and echocardiography results were obtained from medical records.Patients were divided into uric acid(UA)＞420 μmol/L group(n=97),300μmol/L<UA≤420μmol/L group(n=124),and UA≤300μmol/L group(n=90)based on serum UA levels.The logistic regression analysis and ROC curve analysis were used to determine the value of risk factors in predicting HFpEF in elderly patients with AF.Results The mean age of 311 elderly patients with AF was(88.72±4.22)years,and the mean serum uric acid level was(365.14±115.62)μmol/L.Hyperuricemia was found in 33.65%of respondents,and 31.18%of them had serum UA level>420 μmol/L.And compared to the 300μmol/L<UA≤420μmol/L group,UA≤300 μmol/L group,UA>420 μmol/L group had higher levels of serum urea nitrogen and cystatin C(P<0.05),and a higher incidence of hypertension,ejection fraction preserving heart failure,and chronic renal insufficiency(P<0.05).However,the eGFR was slightly lower in the other two groups(P<0.05).UA>420 μmol/L(OR=1.775,95%CI:1.010～3.117)was a marker of HFpEF in elderly patients with AF,and the area under ROC curve was 0.582.Conclusion Serum UA level>420 μmol/L may increase the risk of HFpEF in elderly patients with AF.
Keywords：Atrial fibrillationElderlyHeart failure with preserved ejection fractionHyperuricemia
Publication Date：2023-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1050-1053,1066 )