Expressions of serum fractalkine,β2-microglobulin and tumor necrosis factor α stimulating gene 6 in dilated cardiomyopathy and relationship among them and ventricular remodeling
Yang Kai
Hu Xiaojun
Song Neng
Wu Yongjin
Ye Wei
Abstract：Objective To investigate the expressions of serum fractalkine(FKN),β2-microglobulin(β2-MG)and tumor necrosis factor α stimulating gene 6(TSG-6)in dilated cardiomyopathy(DCM)and relationship among them and ventricular remodeling.Methods DCM patients(n=73)were chosen into case group and healthy controls(n=65)were chosen into control group from Hospital of Integrated Traditional and Western Medicine of Wuhan City from Jan.2021 to Aug 2023.According to NYHA classification of heart function,the case group were divided into grade Ⅱ subgroup(n=22),grade Ⅲ subgroup(n=25)and grade Ⅳ subgroup(n=26).The level changes of serum FKN,β2-MG and TSG-6 were detected and analyzed.The relationship among left atrial diameter(LAD),left ventricular end-diastolic inner diameter(LVEDd),right ventricular diameter(RVD),left ventricular fraction shortening(LVFS)and left ventricular ejection fraction(LVEF)and levels of serum FKN,β2-MG and TSG-6 was analyzed.Results The levels of serum FKN,β2-MG and TSG-6 were significantly higher in case group than those in control group(P<0.05).The levels of serum FKN,β2-MG and TSG-6 were significantly lower in grade Ⅱ subgroup than those in grade Ⅲ subgroup and grade Ⅳ subgroup,and were significantly lower in gradeⅢ subgroup than those in grade Ⅳ subgroup(P<0.05).The levels of LAD,LVEDd and RVD were significantly higher,and levels of LVFS and LVEF were significantly lower in case group than those in control group(P<0.05).The results of correlation analysis showed that levels of serum FKN,β2-MG and TSG-6 were positively correlated to LAD,LVEDd and RVD,and negatively correlated to LVFS and LVEF(P<0.05).Conclusion The expressions of serum FKN,β2-MG and TSG-6 are abnormal,and they are correlated to ventricular remodeling,which may synergistically take part in the occurrence and development of DCM.
Keywords：Dilated cardiomyopathyβ2-microglobulinTumor necrosis factor α stimulating gene 6Ventricular remodeling
Publication Date：2023-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1001-1003 )