Relationship between 25(OH)D level and cardiac function and quality of life in elderly patients with HFpEF
Wang Ting
Fu Jianli
Wu Zhaoke
Zhang Xuemei
Zhao Yuan
Abstract：Objective To evaluate the relationship between 25(OH)D level and cardiac function and quality of life in elderly patients with heart failure with preserved ejection fraction(HFpEF).Methods The 25(OH)D levels of 156 HFpEF patients over 65 years old were compared with those of the same age with normal cardiac function.The HFp EF group was divided into four groups according to the concentration of 25(OH)D.group A with serum 25(OH)D<10 Ug/L,group B with serum 10 Ug/L≤25(OH)D<20 Ug/L,group C with serum 20 Ug/L≤25(OH)D≤30 Ug/L,and group D with serum 25(OH)D>30 Ug/L.NYHA cardiac function assessment,6-minute walking test(6MWT)and Kansas City Cardiomyopathy Questionnaire(KCCQ)were performed in each group.Results Compared with the control group,25(OH)D in the HFpEF group was significantly decreased[16.00(12.82,21.81)vs.14.26(11.26,21.07),P<0.05];Compared with the control group,the 25(OH)D deficiency rate in HFpEF group was significantly increased[90.3%vs.96.2%,P<0.05].The ratio of NYHA ClassⅠ～Ⅱ in group A was lower than that in other groups[(52.0%vs.83.0%),(52.0%vs.81.2%),(52.0%vs.100%),all P<0.05].6MWT in group A was lower than that in other groups[(260.43±40.62 vs.299.91±71.28),(260.43±40.62 vs.324.07±40.62),(260.43±40.62 vs.349.03±60.81),all P<0.05].KCCQ in group A was lower than that in other groups[(61.13±6.80 vs.66.74±6.84),(61.13±6.80 vs.70.79±7.31),(61.13±6.80 vs.72.37±5.78),all P<0.05].Compared with groups C and D,6MWT in group B was worse,but the difference was not significant[(299.91±71.28 vs.324.07±40.62),(299.91±71.28 vs.349.03±60.81),P>0.05].However,KCCQ in group B was significantly lower than that in groups C and D[(66.74±6.84 vs.70.79±7.31),(66.74±6.84 vs.72.37±5.78),both P<0.05].There were no significant differences in 6MWT(324.07±40.62 vs.349.03±60.81,P>0.05)and KCCQ(70.79±7.31 vs.72.37±5.78,P>0.05)between groups C and D.Conclusion The level of 25(OH)D in elderly patients with HFpEF is low.Too low 25(OH)D level is associated with worse cardiac function and quality of life.
Keywords：Vitamin DElderlyHFpEFCardiac functionQuality of life
Publication Date：2023-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 951-953,957 )