Application of early heparinization in patients with ST-segment elevation myocardial infarction before primary percutaneous coronary intervention
Yang Xiu
Lei Mengjie
Zhi Guangshuo
Zhou Haili
Yang Yanli
Li Yachao
Xue Zengming
Abstract：Objective To investigate the application effect of early heparinization in patients with ST-segment elevation myocardial infarction(STEMI)before primary percutaneous coronary intervention(PPCI).Methods STEMI patients(n=548)undergone PPCI were chosen from People's Hospital of Langfang City from Jan.2018 to Dec.2019.All patients were divided,according to heparin treatment time,into early heparin group and late heparin group(each n=274).The early heparin group was given injection of unfractionated heparin(3000 U)immediately after definitive diagnosis in emergency room,and late heparin group was given unfractionated heparin(3000 U)after implanted arterial sheath in catheterization room.After coronary angiography(CAG),the patients in 2 groups were given supplementation of heparin(75～100 U/kg)via arterial sheath if intervention treatment was required.The indexes of TIMI blood flow of culprit vessel,cardiac troponin I(cTnI),N-terminal pro-brain natriuretic peptide(NT-proBNP),and incidence status of major adverse cardiovascular and cerebrovascular events(MACCE)and bleeding events were observed in 2 groups.Results The comparison between early heparin group and late heparin group,the percentage of patients with grade 2 of TIMI was(9.9%vs.6.6%)and that of patients with grade 3 of TIMI was(24.1%vs.11.7%,P<0.05).Conclusion Early heparinization can improve the recanalization rate of culprit vessel,shorten opening time of vessels,relieve myocardial necrosis and improve prognosis in patients with acute myocardial infarction,which is worthy of clinical promotion.
Keywords：ST-segment elevation myocardial infarctionEarly heparinizationPrimary percutaneous coronary interventionTIMI blood flow
Publication Date：2023-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 941-945 )