Inhibition of atherosclerosis by gadolinium doped nano cerium oxide in mice with ApoE gene knockout
Zhang Mimi
Tian Zhimin
Qu Yongquan
Gao Yuan
Abstract：Objective To observe the antagonism of gadolinium doped nano cerium oxide(Ce-Gd)to formation of atherosclerosis(AS)in mice with ApoE gene knockout(ApoE-/-).Methods Ce-Gd(20%)were divided,according to different doses,into normal saline control group(NS group),25 μg/ml group(low-dose group),50 μg/ml group(mid-dose group)and 100 μg/ml group(high-dose group).The influence of Ce-Gd,after treated with lipopolysaccharide(LPS),on levels of plasma inflammatory factors were observed in ApoE-/-mice.A model of ApoE-/-mice with AS was established,and divided into NS infusion group,10 mg/kg Ce-Gd infusion group(low-dose Ce-Gd group)and 50 mg/kg Ce-Gd infusion group(high-dose Ce-Gd group)at time points of 0 d,3 d and 7 d.The area of aortic AS was observed by using oil red O staining,and statistical analysis was carried out in all groups.Results Ce-Gd can decreased levels of plasma inflammatory factors induced by LPS,and AS loading in a dose-independent manner in ApoE-/-mice.Conclusion Ce-Gd can inhibit AS formation through reducing oxidative stress level in ApoE-/-mice,which is expected to become a new anti-atherosclerosis medicinal.
Keywords：AtherosclerosisGadolinium doped nano cerium oxideOxidative stressMice
Publication Date：2023-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 928-931 )