Influence of ticagrelor on levels of plasma visfatin and serum oxidative stress biomarkers and curative effect in patients with coronary heart disease
Zhu Canzhan
Wang Xinhong
Liu Xin
Xue Jiahong
Zhang Mingjuan
Jin Na
Abstract：discuss the influence of ticagrelor on levels of plasma visfatin and serum oxidative stress biomarkers and curative effect in patients with coronary heart disease (CHD). Methods CHD patients (n=95) were chosen from the Second Affiliated Hospital of Xi’an Jiaotong University from Sept. 2015 to Sept. 2017, and then divided randomly into observation group (n=48) and control group (n=47). Besides of the same therapeutic schemes, the control group was conventionally treated with clopidogrel and observation group was treated with ticagrelor for 12 weeks. The levels of plasma visfatin and serum oxidative stress biomarkers, curative effect and incidence of adverse reactions were compared between 2 groups after the treatment finished. Results The total effective rate was 89.58% in observation group and 70.21% in control group (P<0.05). The comparisons in levels of advanced oxidation protein product (AOPP), superoxide dismutase (SOD), malondialdehyde (MDA) and advanced glycation end products (AGEs) showed that observation group was significantly superior to control group after treatment (P<0.01). The level of plasma visfatin was significantly lower in observation group than that in control group after treatment (P<0.01). The incidence rates of adverse reactions were 6.25% in observation group and 21.28% in control group (P<0.05). Conclusion Ticagrelor has significant curative effect, and it can effectively improve the levels of plasma visfatin and serum oxidative stress biomarkers and reduce adverse reactions in CHD patients.
Keywords：TicagrelorCoronary heart diseasePlasma visfatinSerum oxidative stress biomarkers
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1392-1394 )