Comparison in clinical efficacy among levosimendan, nitroglycerin and dobutamine in treatment of acute decompensated heart failure
Pan Youlong
Hu Jinping
Abstract：analyze the influence of levosimendan (LEV), nitroglycerin (NTG) and dobutamine (DOB) on heart function and kidney function in patients with acute decompensated heart failure (ADHF). Methods ADHF patients (n=210) were chosen from Specialist Hospital of Cardiovascular and Cerebrovascular Diseases in Qinghai Province from Jan. 2017 to Apr. 2018. The patients were divided, according to random digital table, into DOB group (with intravenous drip of DOB), NTG group (with intravenous drip of NTG) and LEV group (with intravenous drip of LEV, each n=70). The indexes of left ventricular ejection fraction (LVEF), N-terminal pro-brain natriuretic peptide (NT-proBNP), 6-minute walk distance (6MWD), high sensitivity C-reactive protein (hs-CRP), cardiac troponin I (cTnI), glomerular filtration rate (GFR), blood urea nitrogen (BUN), serum creatinine (SCr), serum cystatin C (Cys C) and urine volume were compared among 3 groups after treatment for 72 h. Results Before treatment, the comparison in LVEF, NT-proBNP, 6MWD, and levels hs-CRP and cTnI showed that the difference had no statistical significance among 3 groups (P>0.05). After treatment, LVEF, 6MWD and hs-CRP level increased significantly (P<0.05), and levels of NT-proBNP and cTnI decreased significantly (P<0.05) in 3 groups compared with those before treatment. After treatment, LVEF level, 6MWD and hs-CRP level ascended successively, and levels of NT-proBNP and cTnI descended successively in NTG group, DOB group and LEV group (P<0.05). Before treatment, the comparison in GFR, BUN, Scr, Cys-C and 72-h urine volume showed that the difference had no statistical significance among 3 groups (P>0.05). After treatment, the difference in above indexes had no statistical significance in NTG group and DOB group (P>0.05) compared with those before treatment. In LEV group, GFR and 72-h urine volume were higher, and levels of BUN, Scr and Cys-C were lower after treatment than those before treatment (all P<0.05). Conclusion LEV has higher improving effect on heart function and kidney function compared with NTG and DOB in ADHF patients.
Keywords：LevosimendanNitroglycerinDobutamineAcute decompensated heart failurePrognosis
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1371-1374 )