Preventive effect of oral nicorandil on contrast-induced nephropathy in patients with acute ST-segment elevation myocardial infarction after primary percutaneous coronary intervention
Fan Yanming
Cai Junna
Zhang Bo
Zhou Bin
Qi Zheng
Wei Qingmin
Abstract：investigate the influence of oral nicorandil on the incidence rate of contrast-induced nephropathy (CIN) in patients with acute ST-segment elevation myocardial infarction (STEMI) undergone primary percutaneous coronary intervention (pPCI) during preprocedural period. Methods STEMI patients (n=260) undergone pPCI were chosen from Department of Cardiology in People’s Hospital of Xingtai City of Hebei Province from Sept. 2016 to Jan. 2018, and then divided randomly into nicorandil group (n=132) and control group (n=128). The nicorandil group was orally given nicorandil (10 mg) after definite STEMI diagnosis followed by nicorandil (10 mg once) and twice a day for 3 d continuously. The control group was given other drugs except of nicorandil. The levels of serum creatinine (SCr) and serum cystatin C (Cys C) were detected at time points of immediate time after admission and after pPCI for 24 h, 48 h, 72 h and 7 d in all groups. The study endpoint was CIN incidence after PCI and the changes of SCr and Cys-C within 7 d after pPCI. Results There were 41 patients (15.77%) with CIN after pPCI. The incidence rate of CIN was significantly lower in nicorandil group than that in control group (10.61% vs. 21.09%, P=0.031). The levels of SCr and Cys-C increased significantly compared with baseline in 2 groups after 24 h, 48 h and 72 h, and recovered to baseline level after 7 d. The levels of SCr and Cys-C were significantly lower in nicorandil group than those in control group after 48 h and 72 h (all P<0.05). The levels of SCr and Cys-C had no statistical difference between 2 groups after 24 h and 7 d (all P>0.05). Conclusion Nicorandil taken orally in perioperative period of pPCI can significantly reduce the postoperative incidence rate of CIN in STEMI patients, which provide a new drug choice for preventing CIN.
Keywords：NicorandilAcute ST-segment elevation myocardial infarctionContrast-induced nephropathyPercutaneous coronary intervention
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1333-1336 )