Influence of pulse pressure on prognosis in patients with type 2 diabetes mellitus complicated by acute ST-segment elevation myocardial infarction
Chen Yanmei
Yao Lu
Wang Xue
Liu Lixin
Wu Yuntao
Zhang Wei
Abstract：investigate the influence of pulse pressure (PP) on prognosis in patients with type 2 diabetes mellitus (T2DM) complicated by acute ST-segment elevation myocardial infarction (STEMI). Methods STEMI patients (n=125) were chosen from the Fourth Department of Geriatrics in the Seventh Medical Center of Chinese PLA General Hospital from July 2015 to June 2018, and divided into T2DM+STEMI group (n=56) and STEMI group (n=69). All patients in 2 groups were given risk scoring by using Global Registry of Acute Coronary Events (GRACE), and the correlation between risk factors and prognosis was analyzed. Results The risk score of GRACE, Gensini integrals, PP, mean systolic blood pressure (SBP), fasting plasma glucose (FPG), lycated hemoglobin (HbAlc), low-density lipoprotein-cholesterol (LDL-C) and apolipoprotein B (ApoB) were all higher in T2DM+STEMI group than those in STEMI group (all P<0.05). The levels of high-density lipoprotein-cholesterol (HDL-C) and apolipoprotein A (ApoA) was not lower in T2DM+STEMI group than those in STEMI group (all P<0.05). The incidence rate of major adverse cardiovascular events (MACE) was significantly higher in T2DM+STEMI group than that in STEMI group (P<0.05). The results of Logistic regression analysis showed that the incidence of MACE was positively correlated to PP, LDL-C, GRACE risk score and Gensini score (β=0.539, β=0.245, β=0.092, β=1.917, all P<0.05). Conclusion PP level and LDL-C can affect significantly the prognosis in STEMI patients, so the controlling of PP level and blood fat should be paid attention to in patients with T2DM complicated by acute cardiovascular events.
Keywords：Acute ST-segment elevation myocardial infarctionType 2 diabetes mellitusPulse pressure
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1319-1321 )