Interpretation on the application of GRADE approach in systematic review of animal studies
Zhao Bing
Jiang Yanbiao
Shang Zhizhong
Zhang Zhewen
Zhang Ting
Geng Jinsong
Li Bo
Ma Bin
Abstract：Objective We interpreted the application principles of GRADE approach in systematic review of animal studies, which promote its correct understanding and using. Methods Based on the sample literature, the application principle of GRADE system in approach in systematic review of animal studies was explained in detail. Results In the sample literature, ＂mortality＂ indicators were downgraded in terms of inaccuracy, publication bias, and indirection, and the quality of evidence was rated ＂very low＂. Conclusion The GRADE system is recommended as a tool to evaluate the quality of evidence in systematic reviews of animal experiment, but there are still some items, such as 1) how to calculate OIS and define the clinically relevant threshold (imprecision); 2) it is still necessary to explore and improve how to refine and standardize the intra-species and inter-species consistency (inconsistency) evaluation system of animal experiments in the future.
Keywords：[Key Words] Grades of Recommendations AssessmentDevelopment and EvaluationSystematic Review or Meta-Analysis of animal experimentInterpretation
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1285-1287 )