Curative effect of felodipine combined with trimetazidine and its influence on coronary artery endothelial function and platelet activity in patients with coronary heart disease-angina pectoris
Lin Keqiang
Wang Shiqi
Huang Caibo
Su Binjie
Wang Xiaoying
Zhang Weilang
Ying Qianliang
Xue Xiaobo
Abstract：investigate the curative effect of felodipine combined with trimetazidine and its influence on coronary artery endothelial function and platelet activity in patients with coronary heart disease-angina pectoris (CHD-AP). Methods The patients with CHD-AP (n=98) were chosen from the First Hospital of Ninghai County from Jan. 2017 to Dec. 2018, and were divided randomly into control group (n=51) and observation group (n=47). The control group was treated with trimetazidine and observation group was treated with felodipine combined with trimetazidine. The curative effect, attack times and duration of CHD-AP, scores of Seattle Angina Questionnaire (SAQ), coronary artery endothelial function and platelet activity before and after treatment and incidence of adverse reactions were compared between 2 groups. Results The total effective rate was higher in observation group than that in control grouop (P<0.05). Before treatment, the difference in attack times and duration of CHD-AP, SAQ scores, coronary artery endothelial function and platelet activity had no statistical significance between 2 groups (all P>0.05). After treatment, the attack times and duration of CHD-AP, endothelin-1 (ET-1) and platelet activity all decreased and were lower in observation group than those in control group, and SAQ scores and nitric oxide (NO) increased and were higher in observation group than those in control group (P<0.05). The total incidence rate of adverse reactions had no statistical difference between 2 groups (P>0.05). Conclusion Felodipine combined with trimetazidine can promote the curative effect on CHD-AP, improve coronary artery endothelial function, inhibit platelet activity and control effectively the disease.
Keywords：Angina pectoris of coronary heart diseaseFelodipineTrimetazidineCurative effectCoronary artery endothelial functionPlatelet activity
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1251-1254 )