Influence of NT-proBNP target-directed treatment on short-term prognosis and heart function of chronic heart failure
Li Ping
Li Wenjia
Wang Xiaoqin
Abstract：investigate the influence of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) target-directed treatment on short-term prognosis and heart function in patients with chronic heart failure (CHF). Methods CHF patients (n=96) were chosen from the First Affiliated Hospital of Medical School of Xi’an Jiaotong University from Feb. 2017 to Feb. 2019, and divided randomly into control group and observation group (each n=48). The control group was given medication treatment according to patients’ symptoms and signs, and observation group was given medication treatment according to dynamic monitoring of NT-proBNP level. The clinical efficacy, heart function indexes [left ventricular ejection fraction (LVEF), left ventricular end-systolic diameter (LVESd), cardiac output (CO), stroke volume (SV), 6-minute walk distance (6MWD) and cardiac index (CI)] and level of plasma NT-proBNP were compared between 2 groups. The re-hospitalization rate and mortality within 3 months after discharging were recorded in 2 groups. Results The total effective rate was significantly increased in observation group compared with control group (87.50% vs. 75.00%, P<0.05). After treatment for 3 months, the levels of LVEF, CO, SV, 6MWS and CI increased significantly (P<0.05) and LVESd level decreased significantly (P<0.05) in observation group compared with control group. After treatment for 3 months, the level of plasma NT-proBNP decreased, and was significantly lower in observation group than that in control group (P<0.05). The re-hospitalization rate (8.33% vs. 18.75%) and mortality (0 vs. 6.25%) within 3 months after discharging were significantly lower in observation group than those in control group (P<0.05). Conclusion The dynamic monitoring of plasma NT-proBNP level and treatment according to monitoring results can significantly promote short-term curative effect, improve heart function, reduce plasma NT-proBNP level and decrease re-hospitalization rate and mortality in CHF patients.
Keywords：Chronic heart failureShort-term prognosisPlasma N-terminal pro-brain natriuretic peptideHeart function
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1241-1243 )