Clinical significance of N-terminal pro-brain natriuretic peptide in heart failure with normal left ventricular ejection fraction
Han Jing
Xue Jun
Liu Weiyuan
Hu Xing
Meng Fankun
Abstract：discuss the change rules and clinical significance of N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with heart failure with normal left ventricular ejection fraction (HFNEF), and to assist clinical diagnosis and treatment. Methods HFNEF patients (n=102, study group) were chosen from Beijing You’ an Hospital of Capital University of Medical Sciences from June 2017 to June 2019. The patients were divided into groups according to grading of heart function and conventional echocardiographic parameters including ratio of peak value of mitral early diastolic flow velocity to peak value of late diastolic flow velocity (E/A) and ratio of peak value of mitral early diastolic flow velocity to peak value of early diastolic motion velocity at mitral annulus root (E/E’). Other patients without HF (n=25) hospitalized at the same time were chosen as controls (control group). The correlation among level of NT-proBNP, grades of heart function and E/A and E/E’ were analyzed in all groups. Results In study group, the level of NT-proBNP was significantly correlated to grades of heart function (506.56±192.886, 725.34± 80.335, 952.39±195.366, P=0.000), E/A (553.59±211.665, 659.78±152.568, 989.56±198.663, P=0.000) and E/E’ (289.56±125.633, 589.63±114.552, 956.93±158.963, P=0.000) and the difference had statistical significance (P<0.05). Conclusion The changes of NT-proBNP level combined with E/A and E/E’ can well review the heart function status in HFNEF patients, which have positive value to assess the severity of patients’ conditions.
Keywords：N-terminal pro-brain natriuretic peptideHeart failureEchocardiogramTissue Doppler ultrasound examination
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1229-1232 )