Correlation between severity of coronary artery lesions and level of glycated hemoglobin in patients with stable coronary heart disease complicated by type 2 diabetes mellitus
Liu Hongyan
Qin Meiling
Qi Huaxin
Xun Lei
Wang Zhongsu
Abstract：investigate the correlation between severity of coronary artery lesions and level of glycated hemoglobin (HbAlc) in patients with stable coronary heart disease (CHD) complicated by type 2 diabetes mellitus (T2DM). Methods The clinical materials from the patients (n=131) with stable CHD complicated by T2DM, chosen from Department of Cardiology in People’s Hospital of Laiwu City from Jan. 2016 to Jan. 2018, were analyzed retrospectively. All patients were divided, according to SYNTAX integrals, into mild lesion group (n=53), moderate lesion group (n=42) and severe lesion group (n=36). The difference in biochemistry indexes including HbA1c were compared among all groups. The correlation between HbA1c level and SYNTAX integrals was analyzed by using Logistic regression analysis. Results The patients were older with longer CHD course, and the percentages of cases of hyperlipidemia and old myocardial infarction (OMI) were higher in severe lesion group (P<0.05). The level of HbA1c and SYNTAX integrals increased along with the exacerbation of coronary lesions (P<0.05). The correlation analysis showed that HbA1c level was positively correlated to SYNTAX integrals (r=0.663, P<0.05), and multi-factor Logistic regression analysis showed that HbA1c level were independently correlated to SYNTAX integrals (β=1.602, OR=4.963, P<0.001). Conclusion HbA1c level is correlated to SYNTAX integrals, which are important factors influencing the severity of coronary lesions and can be taken to predict disease state in patients with stable CHD complicated by T2DM.
Keywords：Stable coronary heart diseaseType 2 diabetes mellitusSeverity of coronary lesionsSYNTAX integralGlycated hemoglobin
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1179-1182,1191 )