Correlation among serum PTX3, H-FABP and heart function in patients with rheumatic heart disease
Huang Xunzheng
Qiu Linmei
Han Yeguang
Li Chunfang.
Abstract：Objective To discuss the correlation among pentraxins 3 (PTX3), heart fatty acid binding protein (H-FABP) and heart function in patients with rheumatic heart disease (RHD). Methods RHD patients were chosen into observation group (n=55) and meanwhile healthy controls were chosen into control group (n=50) from People’s Hospital of Wenchang City from Sept. 2016 to Sept. 2018. The correlation among PTX3, H-FABP, left ventricular ejection fraction (LVEF) and left ventricular end-diastolic inner diameter (LVEDd) were analyzed. Results The levels of PTX3, H-FABP and LVEDd were significantly higher, and LVEF level was significantly lower in observation group than those in control group (P<0.05). The levels of PTX3, H-FABP and LVEDd were significantly lower, and LVEF level was significantly higher in patients with heart function grade II than those in patients with heart function grades III and IV (P<0.05). Taken LVEF and LVEDD as dependent variables and PTX3 and H-FABP as independent variables, the results of correlation analysis showed that PTX3 and H-FABP were negatively correlated to LVEF (r=-0.610, -0.850, P<0.05), and PTX3 and H-FABP were positively correlated to LVEDd (r=0.461, 0.641, P<0.05). Conclusion The expressions of PTX3 and H-FABP are closely related to severity of disease condition, which can improve disease development in RHD patients.
Keywords：Rheumatic heart diseasePentraxins 3Heart fatty acid binding proteinHeart functionCorrelation
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1112-1114 )