The value of serum SIRT1 level in predicting the prognosis of patients with chronic heart failure
Wang Yudong
Luo Zhuoka
Jiang Yu
Sun Jianhui
Liu Huannian.
Abstract：Objective To investigate the predictive value of serum sirtuin-2 related enzyme 1 (SIRT1) level in patients with chronic heart failure (CHF). Methods From January 2013 to June 2016, 97 patients with CHF were enrolled in the CHF group. According to NYHA classification, CHF group was divided into grade Ⅱ (41 cases), grade Ⅲ (34 cases) and grade Ⅳ (22 cases). Another 40 healthy volunteers who underwent physical examination were selected as control group. The levels of SIRT1 and N-terminal B-type natriuretic peptide (NT-proBNP) in all subjects was detected by Enzyme-linked immunosorbent assay. Left ventricular ejection fraction (LVEF) and left ventricular end-diastolic diameter (LVEDD) was measured by color Doppler echocardiography. The SIRT1, NT-proBNP, LVEF and LVEDD of control group and CHF group and CHF patients with different NYHA grades was compared. Pearson correlation analysis was used to analyze the correlation between SIRT1 and ,LVEF, LVEDD and NT-proBNP, follow up for 2 years, ROC curve was used to analyze the value of SIRT1 in predicting the prognosis of CHF patients. Results The level of serum SIRT1 and LVEF in CHF patients were lower than those in the control group, and with the increase of NYHA grades, the level of SIRT1 and LVEF showed a downward trend, with significant differences between groups (P＜0.05). NT-proBNP and LVEDD of CHF patients were higher than those of the control group. With the increase of NYHA classification, NT-proBNP and LVEDD showed an upward trend, and the difference between the two groups was statistically significant (P＜0.05). Pearson correlation analysis showed that there was a positive correlation between SIRT1 and LVEF in CHF patients, and negatively correlated with NT-proBNP and LVEDD (P＜0.05).The follow-up results showed that 32 patients died of CHF within 2 years. The average serum SIRT1 of survivors was (1160.72±96.39) pg/ml, and that of the dead was (598.24± 114.58) pg/ml, with a significant difference (P＜0.05). ROC curve analysis showed that the area under the curve of serum SIRT1 was 0.755, At this time, the sensitivity and specificity for predicting death was 73.8% and 70.0% respectively. Conclusion The serum SIRT1 level in CHF patients is significantly lower, and the worse the heart function, the lower the level, the predictive value of serum SIRT1 level for the prognosis of CHF patients is high.
Keywords：Silent information regulator 2 related enzyme 1Chronic heart failurePrognosisPredictive value
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1073-1076 )