Relationship between serum GDF-15 level and cardiac function and left ventricular remodeling in patients with congestive heart failure
Guo Lifen
Hu Xiaojun
Yan Kaili.
Abstract：Objective To analyze the relationship among serum growth differentiation factor-15 (GDF-15) level, cardiac function and left ventricular remodeling in patients with chronic congestive heart failure (CHF). Methods From December 2015 to December 2017, CHF patients were selected as the case group (n=90). The case group was divided into NYHA Ⅱ according to the New York Heart Association (NYHA) cardiac function classification. Forty-eight healthy subjects (n=28), NYHA class Ⅲ (n=35), and NYHAIV class (n=27), who were admitted to the hospital at the same time as the control group (n=48). The baseline data of the two groups were collected and compared. The serum GDF-15 level, N-terminal precursor B-type natriuretic peptide (NT-proBNP) level and left ventricular remodeling index including left ventricular end-diastolic stage were analyzed in different NYHA patients and control groups. Internal diameter (LVEDD), left atrial systolic diameter (LAD), left ventricular ejection fraction (EF), and left ventricular short axis shortening rate (FS). The correlation between GDF-15 and NT-proBNP levels and left ventricular remodeling index was analyzed. Results The heart rate, systolic blood pressure and diastolic blood pressure of the case group were significantly higher than the control group, and the difference was statistically significant (P＜0.05). Serum GDF-15, NT-proBNP levels, LVEDD and LAD values in NYHAⅡ group, NYHA class Ⅲ group and NYHAIV group were higher than those in the control group, and increased with the increase of NYHA level, the difference was statistically significant (P＜0.05). The EF and FS values of the NYHA group were lower than those of the control group, and decreased with the increase of NYHA level, the difference was statistically significant (P＜0.05). Serum GDF-15 levels were positively correlated with NT-proBNP levels, LVEDD and LAD values (r=0.598, 0.443, 0.489, P＜0.05), but negatively correlated with EF and FS values (r=-0.617, -0.603, P＜0.05). Conclusion Serum GDF-15 level is related to cardiac function and left ventricular remodeling in CHF patients, and can be used as a marker for diagnosis, evaluation of CHF patients.
Keywords：Chronic congestive heart failureGrowth differentiation factor-15N-terminal precursor B-type natriuretic peptideHeart functionLeft ventricular remodeling
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1069-1072 )