Comparison of predictive value of NLR for recurrence after radiofrequency ablation of paroxysmal and persistent atrial fibrillation
Xia Yi
Yang Yiheng
Liu Dekai
Gao Lianjun
Yin Xiaomeng
Xia Yunlong
Abstract：Objective To investigate the comparison of neutrophil-to-lymphocyte ratio (NLR) for prediction value between paroxysmal atrial fibrillation (PAF) and persistent atrial fibrillation (PEAF) recurrence after radiofrequency catheter ablation (RFCA). Method Five hundred and fifty-four AF patients were included. NLR was calculated from the result of hemocyte analysis. Circumferential pulmonary vein isolation (CPVI) was conducted in PAF, and CPVI combined with linear ablation was conducted in PEAF. The AF recurrence was defined as any episode of atrial tachyarrhythmia, more than 30 seconds that occurred after the 3-month post-ablation blanking period. Result The mean follow-up(13.2±3.6)months. Eighty-seven patients (22.1%) recurred in PAF, and Fifty-one patients (31.9%) recurred in PEAF. In PAF and PEAF, NLR was significantly higher in the recurrence group than in the non-recurrence group (P<0.05). Multivariate Cox regression and ROC curve analysis showed that the predictive value of NLR for PEAF recurrence after RFCA was better than PAF [HR=2.421 (95%CI: 1.688~3.472), P<0.05 vs. HR=2.071 (95%CI: 1.682~2.551), P<0.05; AUC=0.721 (95%CI: 0.633~0.809), P<0.05 vs. AUC=0.688 (95%CI: 0.625~0.751), P<0.05] . The optimal ROC cut-off point of NLR was 2.07 in PAF. The optimal ROC cut-off point of NLR was 2.11 in PEAF. Conclusion NLR is an independent predictor for PAF and PEAF recurrence after RFCA. Moreover, the predictive value of NLR for PEAF recurrence after RFCA is better than PAF. When NLR≥2.07, the recurrence rate of PAF may be significantly increased. When NLR≥2.11, the recurrence rate of PEAF may be significantly increased.
Keywords：Neutrophil-to-lymphocyte ratioAtrial fibrillationRadiofrequency catheter ablationRecurrence
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1002-1005 )