Effects of CYP2C19 polymorphism and platelet hyperresponsiveness on clinical ischemic events after PCI in patients with acute coronary syndrome
Ding Huaisheng
Peng Lingyun
Liu Ankang
Abstract：Objective To study the effects of CYP2C19 polymorphism and platelet hyperresponsiveness on clinical ischemic events after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS). Methods From January 2016 to January 2018, 240 ACS patients who received PCI in Department of Cardiology of Meishan People's Hospital were studied, and all the patients were followed up for 6 months. According to whether the ischemic events occurred, the patients were divided into the event group (52 cases) and the non-event group (188 cases).The general data, biochemical index levels, CYP2C19 polymorphism and platelet hyperresponsiveness of the two groups were compared, and multiple Logistic regression analysis of clinical ischemic events after PCI was performed. Results The proportion of smokers and White blood cell(WBC) level in the event group was higher than the non-event group (P＜0.05). The proportion of CYP2C19 intermediate metabolic + slow-metabolizing genes and platelet hyperresponsiveness in patients of the event group was higher than the non-event group (all P＜0.05). Multiple Logistic regression analysis showed that smoking, WBC, intermediate metabolic +slow-metabolizing type CYP2C19 gene and platelet hyperresponsiveness were all independent risk factors for clinical ischemic events after PCI in ACS patients (all P＜0.05). Conclusion CYP2C19 gene polymorphism and platelet hyperresponsiveness are associated with clinical ischemic events after PCI in patients with ACS, suggesting that scientific interventions for these factors may improve patient outcomes.
Keywords：Acute coronary syndromePercutaneous coronary interventionIschemic eventsCYP2C19 polymorphismPlatelet hyperresponsiveness
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 992-994,998 )