Curative effect of esmolol combined with trimetazidine on acute myocardial infarction and its influence on levels of NT-proBNP, sST2 and PTX3
Li Quan
Chen Guoning
Li Gaojun
Abstract：Objective To discuss the curative effect of esmolol combined with trimetazidine on acute myocardial infarction (AMI) and its influence on levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), soluble suppression of tumorigenicity 2 (sST2) and pentraxin 3 (PTX3). Methods AMI patients (n=90) were chosen from Emergency Department in Hainan Provincial Hospital of Traditional Chinese Medicine from May 2016 to May 2018, and then they were randomly divided into observation group (n=47) and control group (n=43). The control group was treated with trimetazidine and observation group was treated with esmolol combined with trimetazidine. The clinical efficacy, levels of serum NT-proBNP, sST2 and PTX3, left ventricular end-diastolic inner diameter (LVEDd), left ventricular ejection fraction (LVEF), left ventricular end-systolic diameter (LVESd) and adverse reactions were compared between 2 groups. Results After treatment, the total effective rate was higher in observation group than that in control group (95.74% vs. 69.77%, P<0.05). The levels of NT-proBNP, sST2 and PTX3 had no significant differences between 2 groups before treatment and decreased significantly in 2 groups after treatment, and they were significantly lower in observation group than those in control group (P<0.05). The heart function had no significant differences between 2 groups before treatment and was significantly improved in 2 groups after treatment, and LVEDd and LVESd were significantly lower and LVEF significantly higher in observation group than those in control group (P<0.05). The incidence of adverse reactions was 6.38% in observation group and 20.93% in control group (P<0.05). Conclusion The application of esmolol combined with trimetazidine has significant curative effect in AMI patients, which can effectively improve the levels of NT-proBNP, sST2 and PTX3.
Keywords：EsmololTrimetazidineAcute myocardial infarctionN-terminal pro-brain natriuretic peptideSoluble suppression of tumorigenicity 2Pentraxin 3
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 975-977 )