Correlation between plasma homocysteine level and coronary no-reflow phenomenon in patients with acute ST-segment elevation myocardial infarction after emergency percutaneous coronary intervention
Liu Yongguo
Wang Fengxia
Li Anna
Li Guoqing
Abstract：Objective To investigate the relationship between plasma homocysteine level and coronary no-reflow phenomenon in patients with acute ST-segment elevation myocardial infarction after emergency percutaneous coronary intervention (PCI). Method A retrospective cross-sectional analysis was performed to collect the clinical data and angiographic results of 86 patients with acute ST-segment elevation myocardial infarction who underwent emergency PCI from January 2015 to April 2017. All patients were divided into no-reflow group and complete perfusion group according to whether there was coronary no-reflow phenomenon after operation. The plasma homocysteine levels were compared between the two groups. The multivariate logistic regression model was used to analyze the relationship between homocysteine and coronary no-reflow. Results Coronary no-reflow phenomenon occurred in 12 of the 86 patients. Compared with the complete perfusion group, the level of homocysteine in patients with coronary artery no-reflow was significantly higher than that in the complete perfusion group [(18.6±6.8)μmol/L vs. ( 11.2±5.4) μmol/L], the difference was statistically significant (P＜0.05). Multivariate logistic regression model showed that for every 3 μmol/L increase in homocysteine level, the risk of coronary no-reflow phenomenon increased by 24% (OR=1.24, 95%CI:1.10~4.18, P=0.016). Conclusion Elevated plasma homocysteine levels can increase the risk of coronary no-reflow phenomenon after emergency PCI in patients with acute ST-segment elevation myocardial infarction.
Keywords：Acute myocardial infarctionHomocysteineNo-reflow phenomenon
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 935-937 )