Ginkgo Leaf Dropping Pills Combined with Antihypertensive Drugs in the Treatment of Essential Hypertension: A systemic review and meta-analysis
Zhao Mingjuan
Ma Linlu
Li Binghui
Wang Chaoyang
Zeng Xiantao
Liu Xincan
Hui Xuezhi
Abstract：Objective To evaluate the efficacy of Ginkgo biloba dropping pills combined with antihypertensive drugs in the treatment of essential hypertension. Methods Pubmed, EMbase, CBM, CNKI, VIP and Wangfang databases were searched online to collect Randomized controlled trials (RCTs) of Ginkgo biloba dropping pills and essential hypertension. The retrieval time was from the establishment of the database to 30 April 2019. Two researchers independently screened literature, extracted data and assessed the risk of bias included in the study. RevMan 5.3 software was used for meta-analysis. Results A total of 5 RCTs involving 804 patients were included. The results showed that compared with taking antihypertensive drugs alone, Ginkgo biloba dropping pills combined with antihypertensive drugs can significantly improve the total effective rate (RR=1.45, 95%CI:1.22~1.73), clinical symptoms (RR=0.25, 95%CI:0.15~ 0.41), blood pressure (MD=-10.62, 95%CI:-15.52~-5.72), blood lipid (MD=-1.13, 95%CI:-1.32~-0.95), low-density lipoprotein cholesterol (MD=-0.64, 95%CI:-0.72~-0.55), sDR4 level (MD=-2.00, 95%CI:-2.19~-1.81) and sDR5 level (MD=-9.91, 95%CI:-12.21~-7.61) of myocardial apoptosis, endothelial function (MD=-2.10, 95%CI:-2.64~-1.56), and vasodilation(MD=-1.10, 95%CI:-1.77~-0.43). Conclusions Current evidence shows that Ginkgo biloba dropping pills combined with antihypertensive drugs is superior to antihypertensive drugs alone for the treatment of essential hypertension. Due to limited quantity and quality of the included studies, more high quality studies are required to verify above conclusions.
Keywords：Ginkgo Leaf Dropping PillsAntihypertensive DrugsEssential HypertensionSystemic reviewMeta-analysis
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 910-913,918 )