Effect of dexamethasone for conversion of persist atrial fibrillation to sinus rhythm
Liu Shuang
Li Aijun
Han Shasha
Li Xiao
Gao Yan Ling
Wang Pei
Lv Jun Li
Abstract：Objective To investigate whether dexamethasone can increase the success rate of drug conversion in patients with persistent atrial fibrillation (AF) and to explore its mechanism. Methods A total of 82 patients with persistent atrial fibrillation who were admitted to the department of emergency of the Central Hospital of Handan from January 1, 2014 to December 30, 2016 were randomly divided into the control group according to the random number table (41 cases). And the observation group (41 cases), the observation group was given 3 weeks of warfarin and 3 days of dexamethasone before the drug cardioversion, the control group was given 3 weeks of warfarin and 3 days of placebo before the drug cardioversion, and the patients after the drug failure failed Electroacupuncture treatment was performed to compare the effective rate of drug conversion, the time of conversion, the changes of cardiac structural indexes indicated by cardiac ultrasound and the levels of serum inflammatory index C-reactive protein (CRP) and procalcitonin (PCT). Results The atrial fibrillation drug conversion success rate observation group (36.58%) was statistically different from the control group (17.07%) (P<0.05). The heart rate of both groups was decreased after cardioversion and before the cardioversion. The difference was statistically significant (P<0.01). However, there was no significant difference in heart rate between the two groups after cardioversion (P>0.05). The left ventricular posterior wall thickness of the observation group was thinner than that of the control group after cardioversion (P<0.05). The systolic blood pressure of the observation group was lower than that before the cardioversion (P<0.05). There were no significant differences in left atrial diameter, left ventricular ejection fraction, and diastolic compression ratio (P>0.05). The CRP and PCT levels in the observation group were significantly lower than those in the control group at 1 day, 2 days, and 3 days after treatment. The difference was statistically significant (P<0.05). Conclusions Dexamethasone can enhance the ability of drug cardioversion atrial fibrillation by decreases inflammation.
Keywords：DexamethasoneC-reactive proteinProcalcitoninPersist atrial fibrillationDrug cardioversion
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 866-870 )