Influence of high-sodium diet on levels of endothelial-derived vasoactive substances
Wang Lili
Zhang Jingyi
Guo Yifang
Wang Chao
Zhang Qianhui
Jin Yali
Abstract：Objective To observe the concentration of endothelin-1 (ET-1), nitric oxide (NO), endothelial nitric oxide synthase (eNOS) and expression of eNOS mRNA in plasma and myocardial tissue, and discuss the molecular biological mechanism of vascular endothelial system in rats with high-sodium diet. Methods SD rats (n=84) were divided randomly into high-sodium diet group (with oral 0.9% NaCL solution) and control group (with oral deionized water, each n=42). All groups were given adaptive feeding for 2 wk and experimental feeding for 8 wk. The concentration of ET-1, NO and eNOS and expression of eNOS mRNA in plasma and myocardial tissue were detected respectively. Results The level of serum sodium and plasma ET-1 concentration were significantly higher (P<0.05) and concentration of plasma eNOS and NO were significantly lower (P<0.05) in high-sodium diet group than those in control group. The concentration of NO and eNOS and eNOS mRNA expression in myocardial tissue were significantly lower (P<0.05), and ET-1 concentration in myocardial tissue was significantly higher (P<0.05) in high-sodium diet group than those in control group. Conclusion This study indicates further that high-sodium diet can induce atherosclerotic vascular lesions and target organ damage through influencing the function of vascular endothelial system.
Keywords：High-sodium dietEndothelial-derived vasoactive substancesAtherosclerosisRats
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 838-840 )