Relationship among galectin 3, microalbuminuria and left ventricular hypertrophy in hypertensive patients
Ye Sha
Wang Chunya
Pan Longfei
Gao Jie
Abstract：Objective To discuss the relationship among galectin 3 (Gal-3), microalbuminuria (MAU) and left ventricular hypertrophy (LVH) in hypertensive patients. Methods The hypertensive patients with LVH (n=79, study group) and hypertensive patients without LVH (n=80, control group) were chosen from Department of Geriatric Cardiovascular Medicine in Second Affiliated Hospital of Xi’an Jiaotong University from Jan. 2016 to June 2017. The data of disease history was investigated and analyzed, and levels of Gal-3 and MAU were detected in 2 groups. The influencing factors of LVH were analyzed by using single-factor and multi-factor regression analysis in hypertensive patients. Results The levels of Gal-3 and MAU were higher in study group than those in control group (P<0.05). The results of Logistic regression analysis showed that hypertensive course≥5 years, failure of hypertension control, Gal-3≥16.27 ng/ml and MAU≥28.75 mg/g were independent risk factors of LVH in hypertensive patients (P<0.05). The results of ROC analysis showed that AUC of Gal-3 was 0.803 and AUC of MAU was 0.825. Conclusion Hypertensive course≥5 years, failure of hypertension control, Gal-3≥16.27 ng/ml and MAU≥28.75 mg/g are independent risk factors of LVH in hypertensive patients. The detections of Gal-3 and MAU have some clinical application value to the prevention and treatment of LVH.
Keywords：Galectin 3MicroalbuminuriaHypertensionLeft ventricular hypertrophy
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 814-817 )