Analysis of current status of cell experimental system evaluation/Meta-analysis
Hu Kaiyan
Zhang Weiyi
Zhang Ting
Chen Jinghong
Zhu Min
Meng Yang
Song Wenjuan
Ma Bin
Zhao Fei
Abstract：Objectives To comprehensive analysis the current research status and existing problems of systematic reviews (SRs) / meta-analysis (MAs) of cell experiments published at home and abroad, so as to provide a reference for future research. Methods The computer retrieved PubMed, China Knowledge Network (CNKI) and Wanfang Data Resources (Wangfang Data), and included the domestically published cell experiments SRs/MAs research, without limiting the source of the cells. The search time limit was built in October 2017. Two investigators screened and extracted data according to inclusion and exclusion criteria, and descriptively analyzed the characteristics of the included studies. Results Finally, 82 SRs/MAs were included in the cell experiments, including 79 in English and 3 in Chinese. Of the 14 (17.07%, 14/82) studies, the number of citations was zero, and the number of citations exceeding 10 was 43 (52.44%, 43/82). In terms of methodology, more than 80% (81.71%, 67/82) did not assess the risk of bias in the included studies. Conclusion The number of published SRs/MAs of cell experiments is small, the rate of citation is low and there are also many methodological problems at present. Therefore, it is urgent to develop and formulate standard production processes and reporting specifications for SRs/Mas of cell experiment in the future to promote the improvement of the methods and reporting quality of it, and achieve the goal of promoting the transformation and utilization of its research result.
Keywords：Cell experimentsSystematic reviewsMeta-analysis
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 778-781 )