Expression levels and clinical significance of serum mi R-133a and mi R-150 in patients with atrial fibrillation
Sun Jie
Tong Zichuan
Guo Limin
Tang Xuehong
Abstract：To investigate the expression and clinical significance of serum mi R-133a and mi R-150 in patients with atrial fibrillation (AF). Methods 73 patients with atrial fibrillation (21 cases of paroxysmal atrial fibrillation, 28 cases of persistent atrial fibrillation, 24 cases of permanent atrial fibrillation) were selected as the study subjects, 25 healthy people were taken as control, the expression levels of serum mi R-133a and mi R-150 were detected by q RT-PCR. At the same time, Pearson method was used to analyze the correlations between mi R-133a and mi R-150 with other serum indicators. ROC curve was used to analyze the values of mi R-133a, mi R-150, and their combination in the diagnosis of atrial fibrillation. Logistic regression analysis was used to analyze the influencing factors of atrial fibrillation. Results Compared with the control group, the level of serum mi R-133a in patients with atrial fibrillation was significantly higher (P＜0.05), and the level of mi R-150 was significantly lower (P＜0.05). There were also significant differences between paroxysmal atrial fibrillation, persistent atrial fibrillation, and permanent atrial fibrillation (P＜0.05). Pearson correlation analysis showed that serum mi R-133a was positively correlated with hs-CRP, left atrial diameter, and MMP-9 in patients with atrial fibrillation (P＜0.05), and negatively correlated with LVEF (P < 0.05). Mi R-150 was negatively correlated with hs-CRP, left atrial diameter, and MMP-9 (P＜0.05), and positively correlated with LVEF (P＜0.05). Compared with the single diagnoses of mi R-133a and mi R-150, the sensitivity, specificity, and area under ROC curve (AUC) of the combined diagnosis were significantly improved (P < 0.05). Logistic regression analysis showed that mi R-133a and mi R-150 were also factors affecting atrial fibrillation. Conclusion The expressions of serum mi R-133a and mi R-150 in patients with atrial fibrillation are abnormal, it may be involved in the occurrence and development of atrial fibrillation, and can be used as assistant indexes for diagnosis of atrial fibrillation and prognosis judgment.
Keywords：Atrial fibrillationSerumMi R-133aMi R-150Clinical significance
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 742-745 )