Changes and clinical significance of levels of plasma tissue inhibitor of metalloproteinase-4 and soluble E-selectin in patients with chronic heart failure
Wang Huailong
Li Geli
Tang Chao
Ji Faming
Nie Suqin
Xu Feng
Abstract：To analyze the changes and clinical significance of levels of plasma tissue inhibitor of metalloproteinase-4 (TIMP-4) and soluble E-selectin (s ES) in patients with chronic heart failure (CHF). Methods CHF patients (n=185) were chosen (CHF group) from Dongguan Taixin Hospital from May 2015 to May 2017. The CHF group was further divided, according to NYHA classification of heart function, into group I (n=30), group II (n=59), group III (n=63) and group IV (n=33). At the same time the healthy controls (n=50) were chosen into control group. The levels of plasma TIMP-4 and s ES, B-type natriuretic peptide (BNP) and left ventricular ejection fraction (LVEF) were compared among all groups. The correlation among TIMP-4 and s ES, BNP and LVEF, and predictive value of TIMP-4 and s ES to CHF diagnosis were analyzed. Results The levels of TIMP-4 and LVEF were significantly lower in CHF group than those in control group, and they decreased significantly along with the increase of NYHA classification of heart function. The levels of s ES and BN were significantly higher in CHF group than those in control group, and they increased significantly along with the increase of NYHA classification of heart function (P<0.05). The results of Pearson correlation coefficient analysis showed that TIMP-4 was negatively correlated to BNP (r=-0.743) and positively correlated to LVEF (r=0.651) in CHF patients. The level of s ES was positively correlated to BNP (r=0.757) and negatively correlated to LVEF (Rs=-0.598). The area under curve (AUC) of receiver operating characteristic (ROC) curve of TIMP-4 was 0.918, that of s ES was 0.732 and that of BNP was 0.895 in CHF diagnosis. The diagnostic value of TIMP-4, s ES and BNP combination (AUC=0.985) was significantly higher than that of BNP alone (AUC=0.895), and specificity was 89.9% and sensitivity was 95.3%. Conclusion TIMP-4 and s ES can effectively reflect the severity of CHF in CHF patients with higher clinical value to the diagnosis and severity review of CHF.
Keywords：Chronic heart failureTissue inhibitor of metalloproteinase-4Soluble E-selectin
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 702-704,708 )