Clinical significance of detection of serum RBP4, hs-CRP and IL-6 levels in patients with coronary heart disease

Huang Le; Lin Dezhi; Ni Wei; Duan Bingjun

doi:10.3969/j.issn.1674-4055.2019.06.11

Abstract：To investigate the clinical significance of detecting serum retinol binding protein 4 (RBP4), high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) in patients with coronary heart disease (CHD). Methods A total of 142 patients with CHD in the First People's Hospital of Neijiang from January 2017 to January 2018 were enrolled in the study. Another 50 healthy subjects were selected as the control group. The serum levels of hs-CRP, IL-6 and RBP4 were compared. The correlation between serum hs-CRP, IL-6 and RBP4 in patients with CHD and coronary heart disease was analyzed. Results The serum level of hs-CRP, IL-6 and BRP4 in myocardial infarction group, unstable angina pectoris group and stable angina pectoris group was significantly higher than that in control group. The serum level of hs-CRP, IL-6 and BRP4 in the myocardial infarction group and the unstable angina pectoris group was significantly higher than that in the stable angina pectoris group (P<0.05). The serum level of hs-CRP, IL-6 and BRP4 in patients with coronary heart disease increased gradually with the increase of the number of lesions and the degree of lesions, there was significant difference in the serum level of hs-CRP, IL-6 and BRP4 in patients with coronary heart disease with different lesions and the degree of lesions (P<0.05). Pearson correlation analysis showed that serum RBP4 was positively correlated with the expression of hs-CRP and IL-6 in CHD patients (r=0.476, 0.584, P<0.05), and the serum RBP4, hs-CRP, IL-6 was positively correlated with the Gensini score (r=0.672, 0.574, 0.465, P<0.05). Conclusion The elevated levels of RBP4, hs-CRP and IL-6 can reflect the extent and stenosis of coronary artery disease in CHD patients.