Relationship between circulating PCSK9 level and lipid metabolism and carotid atherosclerosis in patients with coronary heart disease
Lin Runjie
Wei Jinkun
Zhou Lihong
Abstract：To investigate the correlation between serum circulating proprotein convertase subtilisin kexin type 9 (PCSK9) level and lipid metabolism and carotid atherosclerosis in patients with coronary heart disease (CHD). Methods 127 patients with CHD diagnosed by coronary angiography in Zhongshan Xiaolan people's Hospital from December 2016 to April 2018 were selected. 93 patients with normal coronary angiography were selected as control group. The history of hypertension, diabetes mellitus, family history of CHD, smoking and lipid metabolism was recorded in two groups. The levels of lipid metabolism, hypersensitivity C reactive protein (hs-CRP) and PCSK9 in the two groups was investigated. Carotid intima media thickness (IMT) was also measured to assess the degree of carotid atherosclerosis. Multivariate Logistic regression analysis was used to analyze CHD related risk factors. Pearson correlation was used to analyze the correlation between serum circulating PCSK9 level and other indexes in CHD patients. Resutls The proportion of hypertension, diabetes, smoking, and abnormal lipid metabolism in the CHD group was significantly higher than that of the control group (P<0.05). The level of serum TC, LDL-C, Lp(a), fasting blood glucose, hs-CRP, PCSK9, and common carotid artery IMT in the CHD group was significantly higher than control group (P<0.05), while the level of HDL-C was lower than control group (P<0.05). There was no significant difference in the level of TG, Apo A1, Apo B and FFA between the two groups (P>0.05). Logistic analysis showed that hypertension, LDL-C, Lp(a), PCSK9 and carotid artery IMT was independent risk factor of CHD (P<0.05), while HDL-C was an independent protective factor of CHD (P<0.05). Pearson correlation analysis showed that serum PCSK9 level in CHD group was positively correlated with TC, LDL-C, Apo A1, Apo B, hs-CRP and IMT(P<0.05). Conclusion The increase of PCSK9 level in serum circulation of CHD patients can increase the level of blood lipid, promote inflammatory reaction and promote the occurrence and development of carotid atherosclerosis, which is a risk factor for CHD.
Keywords：Proprotein convertase subtilisin kexin type 9Lipid metabolismCarotid atherosclerosisCoronary heart disease
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 684-687 )