Influence of atorvastatin in sequential and intensive doses on clinical efficacy and serum indexes in elderly patients with coronary heart disease received stent implantation
Jia Dequan
Wei Xiaomei
Li Peilun
Abstract：Objective To study the influence of atorvastatin in sequential and intensive doses on clinical efficacy and serum indexes in elderly patients with coronary heart disease (CHD) received stent implantation. Methods The elderly CHD patients (n=177) were chosen from People’s Hospital of Linyi City from Mar. 2015 to Apr. 2016, and all patients were received first-time stent implantation. All patients were divided, according to random digital table, into control group (n=88) and study group (n=89). The control group was given atorvastatin in intensive dose and study group was given atorvastatin in sequential dose. The levels of blood pressure (BP), ejection fraction (EF) and serum indexes were compared between 2 groups. The incidence of major adverse cardiovascular events (MACE), results of coronary angiography (CAG) and adverse reactions during treatment period were compared between 2 groups 12 months after treatment. Results The levels of systolic blood pressure (SBP) and diastolic blood pressure (DBP) were significantly lower and EF was significantly higher in 2 groups after treatment (P<0.05). The levels of TG and LDL-C were significantly lower in 2 groups 1 month and 12 months after treatment, and were significantly lower in 2 groups after 12 months than those after 1 month. The levels of TG and LDL-C were significantly higher in study group than those in control group 12 months after treatment (P<0.05). The incidence of MACE had no statistical difference between 2 groups 12 months after treatment (P>0.05). The results of CAG had no statistical difference between 2 groups 12 months after treatment (P>0.05). There were no new-attack diabetes, myalgia and liver-enzyme abnormalities observed during follow-up period for 12 months. Conclusion Atorvastatin in sequential and intensive doses have no significant difference in effects on levels of BP, EF and serum indexes and results of MACE and CAG, while atorvastatin in sequential dose can reduce drug quantity and optimize medication in elderly CHD patients received stent implantation, which is worth clinical promoting.
Keywords：AgednessCoronary heart diseaseSequential doseIntensive doseBlood fatMajor adverse cardiovascular events
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 623-626 )