Change and clinical significance of plasma Hcy and ADMA levels in patients with H-type hypertension and coronary heart disease

Guo Hua; Jiang Jinzhong; Miao Wei; Tian Shousen; Wang Zhirong

doi:10.3969/j.issn.1674-4055.2019.05.08

Abstract：Objective To study the changes and clinical significance of plasma Homocysteine (Hcy) and Asymmetric dimethylarginine (ADMA) levels in patients with H-type hypertension and coronary atherosclerotic heart disease (CHD). Methods A total of 119 patients with hypertension or suspected coronary heart disease were enrolled. Coronary angiography was performed after admission. The degree of coronary artery stenosis was evaluated by Gensini score. General patient data and medical history were collected, and fasting venous blood was collected for triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), Hcy and ADMA. Multivariate logistic regression was used to analyze the risk factors of coronary heart disease. Results The prevalence of Hcy, ADMA and coronary heart disease in H-type hypertension group was significantly higher than that in non-H type hypertension group (P<0.05). The Gensini score of patients with H-type hypertension and coronary heart disease was significantly higher than that of patients with non-H-type hypertension and coronary heart disease (P<0.05). The level of Hcy in patients with coronary heart disease was positively correlated with ADMA level and Gensini score. Multivariate logistic regression analysis showed that Hcy and ADMA were independent risk factors for the onset of coronary heart disease. Conclusion The levels of Hcy and ADMA in patients with H-type hypertension and CHD were significantly increased, and Hcy level was positively correlated with ADMA level and severity of coronary lesions. Both Hcy and AMDA are risk factors for CHD. Detection of Hcy and AMDA can be used to predict the risk and progression of coronary heart disease in hypertensive patients.