Relationship between expression of peripheral blood miR-423-5p and ventricular remodeling in elderly patients with heart failure

Zhang Hong; Xue Lei; Wang Xihuan

doi:10.3969/j.issn.1674-4055.2019.04.32

Abstract：Objective To investigate the relationship between expression of peripheral blood miR-423-5p and ventricular remodeling in elderly patients with heart failure (HF). Methods The patients (n=187) were chosen from the Second People’s Hospital of Nanyang City from Feb. 2016 to Apr. 2018, and divided, according to ACC/AHA Guideline, into HF group A (n=91) and group B (n=96), and other healthy controls were chosen into group C (n=46). The clinical materials were collected and differences in blood biochemical indexes, cardiac ultrasonography and expression of peripheral blood miR-423-5p were analyzed in 2 groups. The influence factors on ventricular remodeling were analyzed by using multiple Logistic regression models. The value of miR-423-5p for screening pre-HF patients was determined by using curve of receiver operating characteristic (ROC). Results The general clinical materials and blood biochemical indexes were basically the same between group A and group B (P>0.05), while left ventricular end-diastolic inner diameter (LVEDd), interventricular septum thickness of end-diastole (IVSTd), left ventricular posterior wall thickness at end diastole (LVPWTd), left ventricular mass index (LVMI), left ventricular relative wall thickness (RWT) were all higher in group B than those in group A (P<0.05). The expression of peripheral blood miR-423-5p was significantly lower in group C than that in groups A and B (P<0.05), and at the same time it was significantly higher in group B than that in group A (P<0.05). The curve of ROC analysis on miR-423-5p for screening pre-HF patients showed that area under curve (AUC) was 0.721 (95%CI: 0.634~0.797) and cut-off value was 1.27 (P<0.05). The results of Logistic regression analysis showed that peripheral blood miR-423-5p was an independent risk factor influencing on ventricular remodeling (OR=2.385, 95%CI: 1.298~4.382, P<0.05). Conclusion The peripheral blood miR-423-5p can be used in screening of elderly population with pre-HF, which is significantly and independently correlated to ventricular remodeling.