Correlation between serum macrophage migration inhibitory factor and major adverse cardiovascular events in patients with stable angina pectoris complicated by hypertension
Liu Binghua
Wang Siyao
Li Li
Abstract：Objective To discuss the correlation between expression of serum macrophage migration inhibitory factor (MIF) in peripheral blood and major adverse cardiovascular events (MACE) in patients with stable angina pectoris (SAP) complicated by hypertension. Methods SAP patients (n=119, SAP with hypertension group and SAP without hypertension group) and healthy controls (n=45, control group) were chosen from the Second People’ s Hospital of Jingmen City from July 2015 to Dec. 2016. The general data [sex, age and body mass index (BMI)] and level of serum MIF were detected in all groups. The relationship between MIF level and MACE occurrence was analyzed by using multi-factor Logistic regression model in SAP with hypertension group. Results During follow-up period, MACE occurred in 30 cases (44.12%) in SAP with hypertension group, and the morbidity was significantly higher than that in SAP without hypertension group (P<0.05). The level of serum MIF was significantly higher in MACE patients than that in non-MACE patients in SAP with hypertension group (P<0.05). The level of serum MIF was basically the same in MACE patients and non-MACE patients in SAP without hypertension group (P>0.05). The results of multi-factor Logistic correlation analysis showed that MIF increase was an independent risk factor of MACE occurrence in SAP with hypertension group (P<0.05). Conclusion The higher level of serum MIF is correlated to MACE occurrence in patients with SAP complicated by hypertension, which can be taken as an independent predictive index for patients’ prognosis.
Keywords：Macrophage migration inhibitory factorStable angina pectorisHypertensionMajor adverse cardiovascular eventsCorrelation
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 487-490 )