Changes and clinical significance of serum Chemokine level in patients with chronic heart failure
Ma Mingfei
Zhang Chunxiao
Liu Yan
Wang Yixin
Ma Liping
Feng Yan
Yu Ying
Abstract：Objective To discuss the changes and clinical significance of level of serum Chemokine in patients with chronic heart failure (CHF). Methods CHF patients (n=93) were chosen into study group from Beijing Anzhen Hospital affiliated to Capital University of Medical Sciences from Sept. 2013 to Dec. 2017. The study group was divided, according to heart function grading of NYHA, into grade Ⅱ group (n=28), grade Ⅲ group (n=31) and grade Ⅳ group (n=34), and other patients (n=30) with non-CHF arrhythmia were chosen into control group at the same time. The level of serum Chemerin, heart functional indexes including left ventricular ejection fraction (LVEF) and left ventricular end-diastolic inner diameter (LVEDd), and ventricular remodeling indexes including mean wall stress (MWS) and left ventricular mass index (LVMI) were detected and compared in different groups. The correlation among level of serum Chemerin, heart functional indexes and ventricular remodeling indexes was analyzed by using Pearson correlation coefficients. Results The level of serum Chemerin, and LVEDd, MWS and LVMI were significantly higher, and LVEF was significantly lower in study group than those in control group (P<0.05). The comparisons in the level of serum Chemerin, heart functional indexes and ventricular remodeling indexes had statistical significance in grade Ⅱ group, grade Ⅲ group and grade Ⅳgroup (P<0.05). The level of serum Chemerin, and LVEDd, MWS and LVMI increased with the increase of heart function grading, and LVEF decreased with the increase of heart function grading (P<0.05). The results of Pearson correlation analysis showed that the level of serum Chemerin was positively correlation to MWS, LVMI and LVEDD (r=0.396, r=0.462, r=0.513, all P<0.05), and negatively correlated to LVEF (r=-0.429, P<0.05). Conclusion The level of serum Chemerin increases abnormally in CHF patients, and it is closely correlated to ventricular remodeling and heart function. It can be taken as a biological index for diagnosing CHF in clinic.
Keywords：Chronic heart failureSerum ChemokineClinical significanceVentricular remodelingHeart function
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 458-461 )