Analysis on related blood biochemical indexes in patients with cerebral small vessel disease
Hao Yajuan
Qin Xiaojiang
Bai Jianying
Abstract：Objective To study the risk factors of cerebral small vessel disease (CSVD). Methods The patients (n=117), undergone MRI and diagnosed as CSVD, were chosen into CSVD group from Datong Coal Mine General Hospital from Mar. 2016 to Dec. 2017. At the same time the patients (n=159) with non-cerebrovascular disease were chosen into control group from the same hospital. The general clinical therapies and biochemical indexes were compared between 2 groups. Results The age and proportions of male, smoking, drinking, diabetic and hypertensive patients were all significantly higher in CSVD group than those in control group (all P<0.05). The levels of TG, TC, LDL-C, Hcy, hs-CRP and D-dimer were significantly higher, and level of HDL-C was significantly lower in CSVD group than those in control group (all P<0.05). The results of multi-factor Logistic regression analysis showed that age (OR=1.54, 95%CI: 1.42~21.75), hypertension (OR=2.51, 95%CI: 3.53~15.23), TG (OR=2.54, 95%CI: 2.15~7.93), Hcy (OR=1.36, 95%CI: 1.37~13.52), hs-CRP (OR=2.71, 95%CI: 1.24~10.59) and D-dimer (OR=3.33, 95%CI: 2.57~8.34) were all independent risk factors of CSVD. Conclusion The independent risk factors of CSVD include age, hypertension, TG, Hcy, hs-CRP and D-dimer. The prevention and controlling on these risk factors can efficiently reduce CSVD occurrence risk.
Keywords：Cerebral small vessel diseaseRelated blood biochemical indexesAnalysis
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 452-454 )