Changes and clinical significance of serum Galectin-3 level in patients with microvascular angina
Zhuo Fengqiao
Liu Yujie
Huang Zhanhong
Li Shaojing
Abstract：Objective To observe the changes of serum Galectin-3 level in patients with microvascular angina (MVA), and discuss the relationship between Galectin-3 level and MVA invasion. Methods MVA patients (n=93) were chosen into MVA group and patients (n=93) hospitalized due to chest pain with normal results of coronary angiography (CAG) and treadmill exercise test (TET) were randomly chosen into control group from Department of Cardiovascular Medicine of People’s Hospital of Puyang City in Henan Province from Jan. 2015 to Jan. 2018. The levels of serum Galectin-3, high sensitivity C-reactive protein (hs-CRP), endothelin-1 (ET-1), nitric oxide (NO) and relative physiological and biochemical indexes were detected in all groups. The correlation among Galectin-3 and other indexes was analyzed by using Pearson correlation analysis. Results The proportions of patients with hypertension and diabetes (P<0.05), and level of fasting blood glucose (FBG, P<0.05) were significantly higher in MVA group than those in control group. The levels of Galectin-3, hs-CRP and ET-1 were significantly higher (P<0.05) and NO level was significantly lower (P<0.05) in MVA group than those in control group. The results of Pearson correlation analysis showed that Galectin-3 was positively correlated to FBG, hs-CRP and ET-1 (r=0.456, r=0.598, r=0.426; P<0.05) and negatively correlated to NO (r=-0.488; P<0.05). Conclusion The increase of serum Galectin-3 level can be taken as an important index for microvascular fibrosis and predicting inflammation and microvascular endothelial function in MVA patients.
Keywords：Microvascular anginaGalectin-3InflammationMicrovascular fibrosis
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 435-437 )