Correlation between adenosine diphosphate adenosine platelet aggregation and recent cardiovascular events in patients with acute coronary syndrome
Jia Yuan
Bai Shiru
Li Ruyi
Du Rongpin.
Abstract：Objective To analyze the platelet aggregation rate of adenosine diphosphate (ADP) in patients with acute coronary syndrome (ACS) after double antiplatelet therapy and recent major adverse cardiovascular events (MACE) Correlation. Methods 332 patients with acute coronary syndrome who met the inclusion criteria from September 2016 to September 2017 were collected from Hebei Provincial People's Hospital. All patients received oral antiplatelet drugs. According to the last test of ADP platelet aggregation rate before discharge, the patients were divided into group A (n=160 cases of ADP aggregation rate ≤46%) and group B (n=172 cases of ADP aggregation rate＞46% were not up to standard). Clinical follow-up was performed for 6 months, and the incidence of MACE (angina pectoris, myocardial infarction, stent thrombosis, stroke, and cardiac death) was observed. Results The overall MACE incidence in group A was significantly lower than that in group B within 6 months (28.1% vs. 41.3%,P=0.012). The incidence of angina pectoris in group A was less than that in group B within 2 months (24.4% vs. 35.5%,P=0.028). There was no significant difference in the incidence of death, myocardial infarction, stent thrombosis and stroke between the two groups (P>0.05). Multivariate COX regression analysis included variables including group, history of coronary stenting, history of heart failure, left atrial diameter, hypertension, and creatinine. Multivariate COX regression analysis showed that the groups (grouped according to ADP platelet aggregation rate) (HR=1.754,95%CI:1.193~2.578,P=0.004), hypertension (HR=2.373, 95%CI:1.445~3.897,P=0.001), creatinine (HR=1.011,95%CI:1.004~1.019,P=0.004) is an independent risk factor for predicting MACE events. Conclusion ADP -induced platelet aggregation rate, hypertension history and serum creatinine were independent risk factors for predicting the recent occurrence of MACE. Platelet function was reflected by detecting platelet aggregation rate, which helped to find patients with high platelet reactivity (HPR). The antiplatelet therapy in ACS patients with ADP -induced platelet aggregation rate up to standard was more effective, and MACEs were significantly reduced.
Keywords：Acute coronary syndromeADP -induced platelet aggregation rateAntiplatelet therapyMajor adverse cardiovascular events
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 371-375 )