Relationship between hsCRP, apoB/apoA1, blood lipid expression and acute coronary syndrome in premature coronary heart disease
Wen Weiyi
Zhang Shumei
Liu Xiaojian
Chen Qingqun.
Abstract：Objective To investigate the relationship between hsCRP, apoB/apoA1, blood lipid expression and acute coronary syndrome (ACS) in premature coronary heart disease. Methods A total of 110 patients with acute coronary syndrome with premature coronary heart disease admitted to Qingyuan People's Hospital from February 2014 to February 2018 were enrolled in the observation group. Another 118 patients with non-coronary heart disease who were hospitalized for chest pain at the same time but were confirmed to be coronary artery lesions negative by coronary angiography were selected as the control group. The general data of the two groups of patients were counted and the fasting elbow vein blood was taken. Apolipoprotein A1 (apoA1), apolipoprotein B (apoB), high-sensitivity C-reactive protein (hsCRP) and blood glucose (GLU), total cholesterol (TC), triglyceride (TG) by automatic biochemical analyzer High-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), uric acid (UA), and serum creatinine (Scr) levels were measured. Multivariate logistic regression analysis was used to analyze the independent influencing factors of acute coronary syndrome in patients with premature coronary heart disease. The relationship between hsCRP, apoB/apoA1, blood lipid expression and acute coronary syndrome of early onset coronary heart disease was analyzed. Results There was no significant difference in the proportion of age, body mass index (BMI), UA and diabetes history between the two groups (P>0.05). The proportion of males, smoking history, drinking history, family history of coronary heart disease and hypertension history in the observation group was significantly higher than that in the control group (P<0.05), and the levels of Scr and GLU were significantly higher than those in the control group (P<0.05). There was no significant difference in the levels of LDL-C and apoB between the two groups (P>0.05). The levels of serum hsCRP, TC, TG, non-HDL-C and apoB/apoA1 in the observation group were significantly higher than those in the control group (P<0.05), and the levels of apoA1 and HDL-C were significantly lower than those in the control group (P<0.05). Multivariate logistic regression analysis showed that in addition to male, smoking history, and family history of coronary heart disease, hsCRP, TG, HDL-C, non-HDL-C, apoA1, and apoB/apoA1 were all early coronary heart disease acute coronary syndromes. Independent influence factors (P<0.05). Conclusion hsCRP, TG, non-HDL-C, apoB/apoA1 were significantly elevated in peripheral blood of patients with early-onset coronary heart disease and acute coronary syndrome. ApoA1 and HDL-C were significantly decreased in peripheral blood and could be used as predictors.
Keywords：hsCRPapoB/apoA1Blood lipidsPremature coronary heart diseaseAcute coronary syndrome
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 344-348 )