Expression of sTWEAK in peripheral blood of patients with chronic heart failure and its predictive value for recent MACE
Jing Zhancong
Jian Liguo.
Abstract：Objective To investigate the expression characteristics of plasma soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) in patients with chronic heart failure (CHF) and its predictive value for short-term prognosis. Methods 161 patients with CHF who were admitted to the Department of Cardiology of Sanmenxia Third People's Hospital from January 2016 to January 2017 were selected. Another 30 healthy volunteers were selected as the control group. The biochemical parameters and cardiac function of the two groups were compared. The receiver operating characteristic (ROC) curve was used to determine the cut-off value of plasma sTWEAK in CHF patients. According to the cut-off value, CHF patients were divided into low level group and high level group. After 1 year of follow-up, Kaplan-Meier survival curves were used to analyze the time differences between major adverse cardiovascular events (MACE) in the two subgroups, including all-cause death, acute heart failure, acute myocardial infarction, and unstable angina. Results On the next day of admission, the baseline level of plasma sTWEAK in patients with CHF was significantly lower than that in the control group (P<0.05). According to Spearman correlation analysis, plasma sTWEAK was positively correlated with N-terminal brain natriuretic peptide (NT-proBNP) in patients with CHF (r=0.479, P<0.05). The area under the ROC curve was 0.670, and the cut-off value of plasma sTWEAK for the diagnosis of CHF was 192.74 pg/ml (P=0.021). Seventy-two patients were in the sTWEAK high-level group (>192.74 pg/ml), 89 patients in the low-level group (≤192.74 pg/ml), and the mean follow-up (10.78±2.45) months. The incidence of MACE was significantly higher in the sTWEAK high-level group than in the low-level group (P<0.05). According to Kaplan-Meier survival curve analysis, the risk of MACE in the sTWEAK high-level group was significantly higher than that in the low-level group (P<0.05). Conclusion The level of sTWEAK in peripheral blood of patients with chronic heart failure is lower than that of healthy subjects, and it has certain predictive value for the risk of major adverse events in patients with chronic heart failure in the short term.
Keywords：Soluble TWEAKChronic heart failureN-terminal pro-brain natriuretic peptideMajor adverse cardiovascular eventsPrognosis
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 340-343,348 )