Relationship between myocardial capacity overload and brain natriuretic peptide secretion
Xiao Zongwei
Li Hailin
Chen Jian
Gao Ke
Liu Zaoyang.
Abstract：Objective To investigate whether myocardial volume overload is the direct cause of increased brain natriuretic peptide (BNP) secretion in vivo. Methods Ten healthy New Zealand rabbits were randomly divided into control group (n=5) and volume overload group (n=5). An experimental animal model of myocardial capacity overload was established. The control group only gave infusion and maintained the left atrial pressure at the average physiological level (6 mmHg). The electrocardiographic recorder was used to observe and monitor the changes of left ventricular systolic function (LVSP) and electrocardiogram at 15 minutes and 30 minutes after the two groups of pre-expansion and volume overload groups in the capacity overload (control group maintained left atrial pressure at 6 mmHg). Enzyme-linked immunosorbent assay (ELISA) was used to determine the BNP levels in the plasma of the two groups before the experiment, the capacity overload of the overload group and the control group to maintain the left atrial pressure at 6 mmHg immediately, 15 minutes, 30 minutes. Results There was no significant change in LVSP levels in the volume overload group and the control group before and after the experimental procedure. There was no significant difference between the two groups. Immediately after the capacity overload treatment, the myocardial volume of the overload group was significantly increased compared with that before treatment, and reached the highest point (269.17±17.78) pg/ml at the end of the capacity overload treatment, 30 minutes after the capacity overload treatment. The internal recovery to the baseline level before treatment; the BNP level of the control group did not change significantly before and after the whole experiment. ECG monitoring of the volume overload group and the control group showed no changes in ischemia and arrhythmia throughout the experiment. Conclusion Myocardial volume overload is one of the most important and direct causes of brain natriuretic peptide secretion in vivo.
Keywords：Capacity overloadBrain natriuretic peptideSecretion mechanism
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 320-323 )