Detection of serum MiR-140-3p and MiR-142-5p levels and relationship among them and cardiovascular outcomes and mortality in patients with coronary heart disease
Liu Jing
Ma Xinyi.
Abstract：Objective To study the expressions of serum MiR-140-3p and MiR-142-5p, and discuss the relationship among them and cardiovascular outcomes and mortality in patients with coronary heart disease (CHD). Methods CHD patients (n=542) were chosen into CHD group and healthy controls (n=500) were chosen into control group from the Tenth People’s Hospital of Shenyang City from Jan. 2011 to Oct. 2014. The expressions of serum MiR-140-3p and MiR-142-5p were detected by using RT-qPCR, and the relationship among them and cardiovascular outcomes and mortality was analyzed. Results Compared with control group, the expression of miR-140-3p was significantly down-regulated (P<0.01)), and expression of miR-142-5p was significantly up-regulated (P<0.01) in CHD group. The incidence of cardiovascular events and mortality increased significantly in patient with low-expression of miR-140-3p compared with patients with high-expression of miR-140-3p (P<0.01). The incidence of cardiovascular events and mortality decreased significantly in patient with low-expression of miR-142-5p compared with patients with high-expression of miR-142-5p (P<0.01). The results of Logistic analysis showed that miR-140-3p and miR-142-5p were predictive factors of CHD. Conclusion The expressions of serum miR-140-3p and miR-142-5p are abnormal in CHD patients and they are all correlated to cardiovascular outcomes and mortality, which indicates that both of them take part in the occurrence and development of CHD.
Keywords：Coronary heart diseaseMiR-140-3pMiR-142-5pCardiovascular outcomesMortality
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 312-315 )