Predictive value of Lp (a) on atrial fibrillation in elderly patients with chronic heart failure

Zhu Shenshen; Wu Zhaoke; Hu Yanmin

doi:10.3969/j.issn.1674-4055.2019.02.22

Abstract：Objective To investigate the predictive value of lipoprotein a [Lp(a)] on atrial fibrillation (AF) in elderly patients with chronic heart failure (CHF). Methods In this study, 162 elderly patients with CHF who were admitted to the Department of Geriatrics of the Second Affiliated Hospital of Zhengzhou University from February 2014 to February 2017 were selected. According to the history of atrial fibrillation and electrocardiogram at admission, 47 patients were CHF. Combined with AF (AF group), 115 patients did not have atrial fibrillation (non-AF group). The differences of blood biochemical parameters, cardiac function indexes and Lp(a) levels between the two groups were examined and compared, and the diagnostic value of Lp(a) was determined by the receiver operating characteristic (ROC) curve. Results At admission, the levels of glycated hemoglobin, triglyceride, low-density lipoprotein-cholesterol and Lp(a), and cardiac function in the AF group were significantly different from those in the non-AF group (P<0.05). After multivariate logistic regression analysis, elevated Lp(a) levels were independent risk factors for AF in patients with CHF (P<0.05). According to the ROC curve analysis, the serum Lp (a) level was used to determine whether the area under the curve of CHF patients with AF was 0.826 (95%CI:0.748~0.903, P<0.01), and the cutoff value was 345 mg/L. Conclusion Serum Lp(a) levels can be used as predictors of risk of atrial fibrillation in elderly patients with CHF.