Influence of liraglutide combined with metformin on serum chemokine and insulin resistance in patients with diabetes accompanied by coronary heart disease
Guo Jie
Zhang Yu
Sun Yaodong
Jia Wanming
Bian Ya
Wang Yayi
Abstract：Objective To study the influence of liraglutide combined with metformin on serum chemokine and insulin resistance (IR) in patients with diabetes accompanied by coronary heart disease (CHD). Methods The patients (n=80) were chosen from Department of Cardiovascular Medicine of the Second Hospital of Shijiazhuang City from Feb. 2016 to Apr. 2017, and divided randomly into control group and study group (each n=40). The control group was treated with routine therapy and metformin, and study group was treated with liraglutide combined with metformin on the basis of routine therapy. After treatment for 4 weeks, the difference in blood sugar, heart function, serum chemokine, IR and adverse reactions were analyzed between 2 groups. Results The control effects on fasting plasma glucose (FPG, t=2.27, P=0.03), 2-hour postprandial blood glucose (2 hPBG, t=2.04, P=0.04), glycated hemoglobin (HbAlc, t=3.32, P=0.0001), serum chemokine (t=14.15, P<0.01), homeostasis model assessment of insulin resistance (HOMA-IR, t=5.59, P<0.01) and HOMA-β (t=4.29, P<0.01) were significantly higher in study group than those in control group. The improving effects on left ventricular ejection fraction (LVEF, t=11.53, P<0.01), left ventricular end-systolic diameter (LVESd, t=9.46, P<0.01) and left ventricular end-diastolic inner diameter (LVEDd, t=4.85, P<0.01) were higher in study group than those in control group. The difference in adverse reactions had no statistical significance between 2 groups. Conclusion Liraglutide combined with metformin can not only improve blood sugar, serum chemokine and IR, but also protect heart function in patients with diabetes accompanied by CHD, which is worthy of clinic application.
Keywords：LiraglutideMetforminDiabetes accompanied by coronary heart diseaseSerum chemokineInsulin resistance
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 212-214,218 )