Mitochondrial morphology and function maintained by Sofren Injection after cardiomyocyte hypoxia/reoxygenation injury
Wang Yuanbo
Zhu Rongpai
Tian Xin
Abstract：Objective To study mitochondrial morphology and function maintained by Sofren Injection after cardiomyocyte hypoxia/reoxygenation injury. Methods The mitochondrial membrane potential and mitochondrial permeability pore of cardiomyocytes were detected by using flow cytometer. The mitochondrial morphology was observed by using laser scanning confocal microscope (LSCM), and the expression of p-Drp1 protein was detected by using Western blotting assay. Results The mitochondrial membrane potential was increased, mitochondrial permeability pore opening and mitochondrial fission were decreased, p-Drp1 expression was inhibited, and mitochondrial injury was relieved by Sofren Injection after cardiomyocyte hypoxia/reoxygenation injury. Conclusion Sofren Injection can relive cardiomyocyte hypoxia/reoxygenation injury in cardiomyocytes, and protect mitochondrial morphology and function.
Keywords：Sofren InjectionMitochondrionProtective function
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 209-211 )