Correlation between sex hormone binding globulin and sex hormones and LP-PLA2 and A-FABP in postmenopausal women with hypertension
Qu Li
Wei Yongtao
Cao Qingbo
Liu Xiangheng
Abstract：Objective To investigate the correlation of serum inflammatory markers lipoprotein related phospholipase A2 (Lp-PLA2) and fatty acid binding protein (A-FABP) level with sex hormone binding globulin (SHBG), total testosterone (T) and estradiol (E2) in patients with postmenopausal hypertension. Method The study included 235 elderly patients with primary hypertension who were treated and hospitalized in the outpatient department of Qingdao Eighth People's Hospital from August 2014 to October 2015 (both menopause≥5 years). Serum Lp-PLA2 was measured in all subjects. And the A-FABP and SHBG, T and E2 levels, using a hierarchical regression analysis model to explore the relationship between SHBG, T, E2 and Lp-PLA2 and A-FABP. Result Controlling age, body mass index (BMI), waist-to-hip ratio (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FPG), total cholesterol (TC), triglyceride (TG), high density Lp-PLA2 is negatively correlated with SHBG after the effects of lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting insulin (RI), and high-sensitivity C-reactive protein (hs-CRP) on SHBG ( -0.262 ± 0.126, P=0.040), A-FABP (-0.012±0.040, P=0.766) and SHBG had no significant correlation. There was no significant correlation between Lp-PLA2 (-0.013±0.053, P=0.806), A-FABP (-0.006±0.017, P=0.734) and E2. Lp-PLA2 (-0.063±0.130, P=0.630), A-FABP (-0.010±0.041, P=0.812) had no significant correlation with T. Conclusion In postmenopausal women with hypertension without hormone replacement therapy, sex hormone binding globulin is negatively correlated with lipoprotein associated phospholipase A2; total testosterone and estradiol had no correlation with lipoprotein associated phospholipase A2; there was no correlation between adipocyte fatty acid binding protein and sex hormone binding globulin, total testosterone and estradiol.
Keywords：Postmenopausal womenHypertensionHormone binding globulinSex hormoneLipoprotein associated phospholipase A2Adipocyte fatty acid binding protein
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 184-187,191 )