Influence of atorvastatin in intensive dose on level changes of serum monocyte chemoattractant protein-1 and osteopontin in patients with acute myocardial infarction after PCI
Li Juanxia
Fu Zhiya
Chu Jie
Li Na
Abstract：Objective To investigate the influence of atorvastatin in intensive dose on level changes of serum monocyte chemoattractant protein-1 (MCP-1) and osteopontin (OPN) in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). Methods AMI patients (n=82) were chosen from Jianguo Hospital of Zhangjiakou City in Hebei Province from Jan. 2016 to Mar. 2017, and divided, according to random digital table, into routine dose of atorvastatin group (routine group) and intensive dose of atorvastatin group (intensive dose group). The levels of serum OPN, MCP-1 and blood fat were detected before and after PCI in 2 groups, and incidence of major adverse cardiovascular events (MACE) was followed up after 6 months. Results The levels of serum OPN and MCP-1 increased after PCI for 1 d, 1 week, 2 weeks and 4 weeks in 2 groups, and levels of serum OPN and MCP-1 were lower in intensive dose group than those in routine group (P<0.05) at all time points. The levels of LDL-C, TG and TC decreased and level of HDL-C increased in 2 groups after treatment, and levels of LDL-C, TG and TC were lower and level of HDL-C was higher in intensive dose group than those in routine group (P<0.05). LVEF increased in 2 groups after treatment, and was higher in intensive dose group than that in routine group (P<0.05). The incidence of MACE was lower in intensive dose group than that in routine group (4.88% vs. 19.51%, P<0.05). Conclusion Atorvastatin in intensive dose can inhibit the increase of serum MCP-1 and OPN levels, regulate blood fat level, improve heart function and reduce risk of MACE in AMI patients undergone PCI.
Keywords：Intensive doseAtorvastatinAcute myocardial infarctionPercutaneous coronary interventionMonocyte chemoattractant protein-1Osteopontin
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 171-174,183 )