Myocardial protective and preventive effects of nicorandil on in STEMI patients with intra-operative slow or no reflow during PCI
Wu Xiaopeng
Chen Wenbo
Huang Li
Wang Congzhen
Wang Xuanqi
Abstract：To study the myocardial protective and preventive effects of nicorandil on in STEMI patients with intra-operative slow or no reflow during PCI. Methods STEMI patients with intra-operative slow or no reflow during PCI (n=108) were chosen from Department of Cardiovascular Medicine of the Fourth People’ s Hospital of Shaanxi Province from Oct. 2015 to June 2017, and then divided randomly into control group and observation group (each n=54). The control group was given routine symptomatic therapies and observation group was additionally given oral nicorandil. The percentage of patients with resolution≥50% of elevated ST segment related to infarction, serum myocardial injury markers, plasma brain natriuretic peptide (BNP) and indexes of heart structure and function were compared between 2 groups at different time points after PCI. The incidence of adverse cardiovascular events was compared between 2 groups within 30 d after PCI. Results The percentage of patients with resolution≥50% of elevated ST segment related to infarction was significantly higher in observation group than that in control group at time points of immediately, 72 h and 30 d after PCI (P<0.05). The levels of CK-MB and cTnI were significantly lower in observation group than those in control group 24 h after PCI (P<0.01). The level of BNP and values of LVEDD and LVESD were significantly lower (P<0.01), and value of LVEF was significantly higher (P<0.01) in observation group than those in control group 30 d after PCI. The incidences of malignant arrhythmia, severe heart failure and relapse of myocardial infarction were significantly lower in observation group than those in control group 30 d after PCI (P<0.05). Conclusion Nicorandil can relieve myocardial injury, improve recovery of left heart structure and function and reduce incidence risk of adverse cardiovascular events in STEMI patients with intra-operative slow or no reflow during PCI, which is worth to be popularized in clinical practice.
Keywords：NicorandilPercutaneous coronary interventionIntra-operative slow or no reflowAcute ST-segment elevation myocardial infarctionMyocardial protection
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 114-117 )